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[急诊结肠手术:预测发病率和死亡率的危险因素分析]

[Emergency colonic surgery: analysis of risk factors predicting morbidity and mortality].

作者信息

Costa Gianluca, Tomassini Federico, Tierno Simone Maria, Venturini Luigi, Frezza Barbara, Cancrini Giulio, Mero Alessandro, Lepre Luca

机构信息

Dipartimento di Chirurgia, II Facoltà di Medicina e Chirurgia, Università Roma Sapienza, Azienda Ospedaliera Sant'Andrea, Roma.

出版信息

Chir Ital. 2009 Sep-Dec;61(5-6):565-71.

Abstract

The aim of the present study was to identify risk factors for morbidity and mortality in patients submitted to emergency colonic surgery. Between 1997 and 2008 157 patients, 106 of whom affected by colon cancer (67.5%) and 51 by benign disease (32.5%), were treated. The risk factors for morbidity and mortality were evaluated by univariate and multivariate analysis considering clinical and demographic data. The overall 30-day morbidity and mortality rates were 19.1% (30 patients) and 12.7% (20 patients), respectively. Among patients affected by cancer the mortality rate was 15% (16 patients) and the morbidity rate 23.6% (25 patients), while among the patients with benign disease the mortality rate was 7.8% (4 patients) and the morbidity rate 9.8% (5 patients). No postoperative surgical complications were noted. The strongest risk factors for early death were postoperative medical complications such as cardiopulmonary, renal, thrombo-embolic and infectious complications. The results of the univariate analysis showed that advanced age, neoplastic disease, advanced stage of cancer and associated medical disease prior to surgery play a role as risk factors for morbidity and mortality. In the multivariate analysis only the presence of associated medical disease proved to be a significant independent predictor of outcome. Emergency surgery for both neoplastic and benign colonic disease is still associated with an increased risk of death. Although restorative colectomy should be regarded as the first choice procedure in the emergency setting, Hartmann's procedure is still widely used in high-risk patients.

摘要

本研究的目的是确定接受急诊结肠手术患者发病和死亡的风险因素。在1997年至2008年期间,对157例患者进行了治疗,其中106例患有结肠癌(67.5%),51例患有良性疾病(32.5%)。通过单因素和多因素分析,综合考虑临床和人口统计学数据,评估发病和死亡的风险因素。30天的总体发病率和死亡率分别为19.1%(30例患者)和12.7%(20例患者)。在癌症患者中,死亡率为15%(16例患者),发病率为23.6%(25例患者);而在良性疾病患者中,死亡率为7.8%(4例患者),发病率为9.8%(5例患者)。未发现术后手术并发症。早期死亡的最强风险因素是术后医疗并发症,如心肺、肾脏、血栓栓塞和感染性并发症。单因素分析结果显示,高龄、肿瘤性疾病、癌症晚期以及术前合并内科疾病是发病和死亡的风险因素。多因素分析表明,只有合并内科疾病是结局的显著独立预测因素。肿瘤性和良性结肠疾病的急诊手术死亡风险仍然较高。尽管在急诊情况下,恢复性结肠切除术应被视为首选手术,但Hartmann手术仍广泛应用于高危患者。

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