一项基于大规模人群研究的八项血细胞计数测量指标的参考区间。

Reference intervals for eight measurands of the blood count in a large population based study.

作者信息

Ittermann Till, Roser Markus, Wood Graham, Preez Helma, Lüdemann Jan, Völzke Henry, Nauck Matthias

机构信息

Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany.

出版信息

Clin Lab. 2010;56(1-2):9-19.

PMID:20380355

Abstract

BACKGROUND

The blood count is widely used in clinical practice. Well defined reference intervals for each measurand are essential for correct clinical interpretation of results. Most previous studies have not been population-based. We therefore calculated reference intervals for several hematological measurands from a sample of the general adult population of Northeastern Germany.

METHODS AND RESULTS

We used data from 2967 healthy individuals recruited for the population-based Study of Health in Pomerania (SHIP). Reference intervals were calculated according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI) using the bootstrap method for the age range from 20 to 79 years and, in addition, stratified according to age and gender with both bootstrap and quantile regression procedures. Reference ranges for erythrocytes, hemoglobin and hematocrit increased with age in women but decreased in men.

CONCLUSIONS

Our reference intervals were lower than those previously published for erythrocytes, hemoglobin, hematocrit and leukocytes but higher for Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin (MCH). Different laboratory methods and study populations may lead to disparity in results.

摘要

背景

血细胞计数在临床实践中被广泛应用。每个被测量物明确的参考区间对于结果的正确临床解读至关重要。以往大多数研究并非基于人群。因此，我们从德国东北部普通成年人群样本中计算了几种血液学被测量物的参考区间。

方法与结果

我们使用了为基于人群的波美拉尼亚健康研究（SHIP）招募的2967名健康个体的数据。根据临床和实验室标准协会（CLSI）的指南，采用自抽样法计算了20至79岁年龄范围的参考区间，此外，还通过自抽样法和分位数回归程序按年龄和性别进行了分层。女性红细胞、血红蛋白和血细胞比容的参考范围随年龄增加，而男性则下降。