Ittermann Till, Roser Markus, Wood Graham, Preez Helma, Lüdemann Jan, Völzke Henry, Nauck Matthias
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany.
Clin Lab. 2010;56(1-2):9-19.
The blood count is widely used in clinical practice. Well defined reference intervals for each measurand are essential for correct clinical interpretation of results. Most previous studies have not been population-based. We therefore calculated reference intervals for several hematological measurands from a sample of the general adult population of Northeastern Germany.
We used data from 2967 healthy individuals recruited for the population-based Study of Health in Pomerania (SHIP). Reference intervals were calculated according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI) using the bootstrap method for the age range from 20 to 79 years and, in addition, stratified according to age and gender with both bootstrap and quantile regression procedures. Reference ranges for erythrocytes, hemoglobin and hematocrit increased with age in women but decreased in men.
Our reference intervals were lower than those previously published for erythrocytes, hemoglobin, hematocrit and leukocytes but higher for Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin (MCH). Different laboratory methods and study populations may lead to disparity in results.
血细胞计数在临床实践中被广泛应用。每个被测量物明确的参考区间对于结果的正确临床解读至关重要。以往大多数研究并非基于人群。因此，我们从德国东北部普通成年人群样本中计算了几种血液学被测量物的参考区间。
我们使用了为基于人群的波美拉尼亚健康研究（SHIP）招募的2967名健康个体的数据。根据临床和实验室标准协会（CLSI）的指南，采用自抽样法计算了20至79岁年龄范围的参考区间，此外，还通过自抽样法和分位数回归程序按年龄和性别进行了分层。女性红细胞、血红蛋白和血细胞比容的参考范围随年龄增加，而男性则下降。
我们的参考区间低于先前发表的红细胞、血红蛋白、血细胞比容和白细胞的参考区间，但高于平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）的参考区间。不同的实验室方法和研究人群可能导致结果存在差异。
