Richardson-Jones A, Twedt D, Gibson M, Hellman R
Clinical Laboratory, Coulter Corporation, Hialeah, FL 33011.
Ann Clin Lab Sci. 1993 Sep-Oct;23(5):340-9.
Conventional methods for extracting reference values from a sample of a purported normal population have a tendency to include some paranormal individuals and to obscure the existence of marginal or subclinical disorders. The suggestion is offered of defining the normal range of an analyte by extrapolation of the portion of its dispersion that fits a continuum. The method softens the present dichotomous character of the reference range. It narrows the normal range of some hematology parameters, suggesting that some paranormal individuals are excluded.
从所谓正常人群样本中提取参考值的传统方法往往会纳入一些异常个体，并掩盖边缘性或亚临床疾病的存在。有人建议通过外推分析物离散度中符合连续分布的部分来定义其正常范围。该方法缓和了目前参考范围的二分特征。它缩小了一些血液学参数的正常范围，表明一些异常个体被排除在外。
