Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
J Nat Prod. 2010 May 28;73(5):1002-4. doi: 10.1021/np100113e.
Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC(50) value of 70.7 microM. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC(50) value of 9.04 microM.
从白蘑科蘑菇 Boletopsis leucomelas 的子实体中分离得到了三种新型 p-三联苯类化合物，分别命名为 boletopsin A（1）、B（2）和 C（3），以及四种已知类似物（4-7）。测试了化合物 1-7 对 KDR 激酶的抑制活性，发现 boletopsin C（3）的 IC50 值为 70.7μM。化合物 3 还表现出对人脐静脉内皮细胞增殖的抑制作用，IC50 值为 9.04μM。
