Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
J Nat Prod. 2014 Apr 25;77(4):963-8. doi: 10.1021/np401046z. Epub 2014 Mar 6.
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.
从蘑菇 Polyozellus multiplex 中分离得到了一种新型的对三联苯化合物，多氧酸（1）及其丙酮加合物（3），以及一种已知的对三联苯化合物，thelephoric 酸（2）。通过光谱分析、X 射线晶体学分析和化学修饰确定了它们的分子结构。在一些与血管生成相关的测定中，特别是化合物 1 和 2 对人脐静脉内皮细胞的增殖、管形成和侵袭具有抑制作用。这些分子中的醌部分可能有助于它们的抗血管生成活性。
