CECAV, Department of Veterinary Sciences, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.
Res Vet Sci. 2010 Dec;89(3):396-403. doi: 10.1016/j.rvsc.2010.03.016. Epub 2010 Apr 8.
The biological implication of the growth hormone/insulin like growth factor-I (GH/IGF-I) axis in canine mammary tumours (CMT) has been recently demonstrated, however its clinical and prognostic implications are unknown. Our aim was to investigate its prognostic significance. Hormonal determinations were done by enzyme immunoassays techniques validated for canine species in serum and tumour tissue from 32 bitches with CMT and in serum and normal mammary tissue from 10 controls. Serum and tissular GH and IGF-I concentrations were significantly higher in the case of malignant tumour compared with benign and controls. GH and IGF-I elevated concentrations were significantly associated with tumour relapse and/or metastases during follow-up and in dogs with reduced survival times; however these parameters were not independent prognostic factors in multivariate analysis. This association demonstrates a link between high serum and intratumoural GH and IGF-I concentrations and a worse prognosis and opens the possibility to new anticancer endocrine therapies in dogs.
生长激素/胰岛素样生长因子-I（GH/IGF-I）轴在犬乳腺肿瘤（CMT）中的生物学意义最近已经得到证实，但其临床和预后意义尚不清楚。我们的目的是研究其预后意义。通过酶免疫分析技术对 32 只患有 CMT 的母犬的血清和肿瘤组织以及 10 只对照母犬的血清和正常乳腺组织进行了激素测定，这些技术已针对犬种进行了验证。与良性肿瘤和对照组相比，恶性肿瘤的血清和组织 GH 和 IGF-I 浓度明显更高。在随访期间，肿瘤复发和/或转移以及生存时间缩短的犬中，GH 和 IGF-I 的升高浓度与肿瘤复发和/或转移显著相关；然而，在多变量分析中，这些参数并不是独立的预后因素。这种相关性表明，高血清和肿瘤内 GH 和 IGF-I 浓度与预后不良之间存在联系，并为犬的新抗癌内分泌治疗开辟了可能性。
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