Kamińska O, Gruszecka B
Med Pr. 1977;28(5):377-91.
The experiment was carried out on rats, which were divided into three experimental and one control groups. The experimental animals were intraperitoneally injected with furfural in the dose of 58 mg/kg body weight for 30 days. In the liver samples obtained at autopsy, apart from routine staining with hematoxylin and eosin, estimation of the activity of the following enzymes was made: succinic dehydrogenase. NADH-tetrazol reductase, lactic dehydrogenase, glucose-6-phosphate, adenosine-triphosphatase, Ca-formol, glucose-6-phosphatase and acid phosphatase. Glycogen content was also evaluated. A temporary decrease in the activity of reactions for the enzymes of tissue respiration, an increase in the activity of glucose-6-phosphatase with a simultaneous decrease of glycogen content, activation of intracellular digestive processes, and inhibition of active transport through biological membranes were found in animals intoxicated with furfural.
实验在大鼠身上进行，大鼠被分为三个实验组和一个对照组。实验动物腹腔注射糠醛，剂量为58毫克/千克体重，持续30天。在尸检时获得的肝脏样本中，除了用苏木精和伊红进行常规染色外，还对以下酶的活性进行了评估：琥珀酸脱氢酶、NADH-四氮唑还原酶、乳酸脱氢酶、葡萄糖-6-磷酸、腺苷三磷酸酶、钙-福尔马林、葡萄糖-6-磷酸酶和酸性磷酸酶。还评估了糖原含量。在用糠醛中毒的动物中发现，组织呼吸酶反应活性暂时降低，葡萄糖-6-磷酸酶活性增加，同时糖原含量降低，细胞内消化过程激活，以及生物膜主动转运受到抑制。
