Department of Radiation Physics, Radiation Medicine Program, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.
Med Phys. 2010 Mar;37(3):1325-31. doi: 10.1118/1.3327458.
The new model of stereotactic radiosurgery system, Gamma Knife Perfexion, allows automatic selection of built-in collimation, eliminating the need for the time consuming manual collimator installation required with previous models. However, the configuration of sources and collimators inside the system does not permit easy access for the verification of the selected collimation. While the conventional method of exposing a film at the isocenter is useful for obtaining composite dose information, it is difficult to interpret the data in terms of the integrity of each individual source and corresponding collimation. The primary aim of this study was to develop a method of verifying the geometric configuration of the sources and collimator modules of the Gamma Knife Perfexion. In addition, the method was extended to make dose measurements and verify the accuracy of dose distributions calculated by the mathematical formalism used in the treatment planning system, Leksell Gamma Plan.
A panoramic view of all of 192 cobalt sources was simultaneously acquired by exposing a radiochromic film wrapped around the surface of a cylindrical phantom. The center of the phantom was mounted at the isocenter with its axis aligned along the longitudinal axis of the couch. The sizes and shapes of the source images projected on the phantom surface were compared to those calculated based on the manufacturer's design specifications. The measured dose at various points on the film was also compared to calculations using the algorithm of the planning system.
The panoramic images allowed clear identification of each of the 192 sources, verifying source integrity and selected collimator sizes. Dose on the film surface is due to the primary beam as well as phantom scatter and leakage contributions. Therefore, the dose at a point away from the isocenter cannot be determined simply based on the proportionality of collimator output factors; the use of a dose computation algorithm is required. Scatter and leakage dose contributions from neighboring sources were calculated and found to be 6.3% (ranging from 4.5% to 7.4%), 16.7% (12.5%-19.3%), and 66.6% (38%-78%) for the 4, 8, and 16 mm collimators, respectively, at the centers of the source images. The measured average dose on films with 16 mm collimators agrees with the dose model of the treatment planning system to within 1.0%. The average doses on the film were 24.0, 60.8, and 186.2 cGy for 4, 8, and 16 mm diameter collimators, respectively, when the machine was set to deliver a reference dose of 100 Gy to the center of an 80 mm radius spherical dosimetry phantom.
A method of simultaneously capturing and analyzing the panoramic images of 192 cobalt sources has been developed to verify the source and collimator configuration of GK systems. The method was extended to verify the dose calculation model of the treatment planning system by comparing the measured doses on the panoramic film images and the corresponding calculated doses. The method presented can play a significant role in comprehensive commissioning and routine quality assurance testing of the Gamma Knife systems.
新型立体定向放射外科系统伽玛刀 Perfexion 允许自动选择内置准直器,从而省去了以往型号所需的费时的手动准直器安装。然而,系统内部源和准直器的配置不便于对所选准直器进行验证。虽然在等中心处曝光胶片以获取复合剂量信息的传统方法是有用的,但很难根据每个单独源和相应准直器的完整性来解释数据。本研究的主要目的是开发一种验证伽玛刀 Perfexion 源和准直器模块的几何构型的方法。此外,该方法还扩展到进行剂量测量,并验证由治疗计划系统(Leksell GammaPlan)中使用的数学形式主义计算的剂量分布的准确性。
通过在圆柱形模体表面包裹的放射色胶片同时获取所有 192 个钴源的全景图像。模体的中心安装在等中心处,其轴沿着治疗床的纵轴对齐。在模体表面上投影的源图像的大小和形状与制造商的设计规格进行了比较。还比较了胶片上各个点的测量剂量与使用计划系统算法的计算剂量。
全景图像可以清楚地识别出 192 个源中的每一个,从而验证了源的完整性和所选准直器的尺寸。胶片表面的剂量是由初级射束以及模体散射和泄漏贡献的。因此,不能仅根据准直器输出因子的比例关系来确定离等中心较远的点的剂量;需要使用剂量计算算法。计算并发现相邻源的散射和泄漏剂量贡献分别为 4、8 和 16mm 准直器的 6.3%(4.5%-7.4%)、16.7%(12.5%-19.3%)和 66.6%(38%-78%),位于源图像的中心。使用 16mm 准直器的胶片上测量的平均剂量与治疗计划系统的剂量模型相差在 1.0%以内。当机器设置为将 100Gy 的参考剂量输送到 80mm 半径球形剂量测定模体的中心时,胶片上的平均剂量分别为 4、8 和 16mm 直径准直器的 24.0、60.8 和 186.2cGy。
已经开发出一种同时捕获和分析 192 个钴源全景图像的方法,以验证 GK 系统的源和准直器配置。该方法还扩展到通过比较全景胶片图像上的测量剂量和相应的计算剂量来验证治疗计划系统的剂量计算模型。所提出的方法可以在伽玛刀系统的全面调试和常规质量保证测试中发挥重要作用。