中空介孔硅纳米粒子的气溶胶法制备及其作为候选药物载体包封 L-蛋氨酸。
Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of L-methionine as a candidate drug cargo.
机构信息
Department of Chemical and Nuclear Engineering and Center for Micro-Engineered Materials, The University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Chem Commun (Camb). 2010 May 7;46(17):3019-21. doi: 10.1039/b927025f. Epub 2010 Mar 25.
DOI:10.1039/b927025f
PMID:20386854
Abstract
Hollow spherical nanoparticles with ordered mesoporous silica shells were fabricated by evaporation-induced self-assembly using (NH(4))(2)SO(4) and cetyltrimethyl ammonium bromide (CTAB) as templates. The model drug, L-methionine, was encapsulated within the spherical void at high loadings by repeated crystallization.
摘要
采用（NH4）2SO4和十六烷基三甲基溴化铵（CTAB）为模板，通过蒸发诱导自组装制备了具有有序介孔硅壳的中空球形纳米粒子。通过反复结晶，将模型药物 L-蛋氨酸以高载量包封在球形孔内。
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