Yang Dongzhi, Wang Na, Ji Haixia, Sun Shian, Dong Jingjing, Zhong Yuanyuan, Qian Chuntong, Xu Huanghuang
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University Xuzhou Jiangsu 221004 China
Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University Xuzhou Jiangsu 221004 China.
RSC Adv. 2018 Nov 20;8(68):38987-38994. doi: 10.1039/c8ra07193d. eCollection 2018 Nov 16.
Due to excellent optical properties, CdTe quantum dots (QDs) exhibit great potential in cancer imaging. However, CdTe QDs can be quickly cleared out before reaching the desired location because of their ultra-small size. The structure and optical properties of CdTe QDs are also easily affected by the surrounding solution, which leads to their compromised applications . Here, CdTe QDs were incorporated into hollow mesoporous silica nanoparticles (hMSN) to form CdTe@hMSN nano-platforms. The as-synthesized system maintained the excellent emission properties of CdTe QDs; meanwhile, relatively high drug loading efficiency was also observed for doxorubicin (DOX). With the target for vascular endothelial growth factor (VEGF), the formed CdTe@hMSN(DOX)-VEGF Abs showed feasibility of tumor-oriented drug delivery and CdTe@hMSN conjugate accumulation. The high accumulation and enhanced targeted drug delivery of CdTe@hMSN conjugates in tumor nodules confirmed that CdTe@hMSN conjugates can serve as promising candidates for cancer detection and treatment.
由于具有出色的光学性质，碲化镉量子点（QDs）在癌症成像中展现出巨大潜力。然而，碲化镉量子点因其超小尺寸，在到达期望位置之前就会被迅速清除。碲化镉量子点的结构和光学性质也容易受到周围溶液的影响，这导致其应用受到限制。在此，将碲化镉量子点掺入中空介孔二氧化硅纳米颗粒（hMSN）中，以形成CdTe@hMSN纳米平台。所合成的体系保持了碲化镉量子点优异的发光性质；同时，对于阿霉素（DOX）还观察到了相对较高的载药效率。以血管内皮生长因子（VEGF）为靶点，所形成的CdTe@hMSN(DOX)-VEGF抗体显示出肿瘤靶向给药和CdTe@hMSN缀合物积累的可行性。CdTe@hMSN缀合物在肿瘤结节中的高积累和增强的靶向给药证实，CdTe@hMSN缀合物可作为癌症检测和治疗的有前景的候选物。
