Chen Long, Fu Xin, Lin Mei, Jiang Xingmao
Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
Nanjing Zhongwei Biomaterials Research Institute Co., Ltd., Nanjing 210008, China.
Pharmaceuticals (Basel). 2022 Feb 23;15(3):275. doi: 10.3390/ph15030275.
Methods of large-scale controllable production of uniform monodispersed spherical nanoparticles have been one of the research directions of scientists in recent years. In this paper, we report an azeotropic distillation-induced evaporation self-assembly method as a universal method, and monodispersed hydrophobic ordered mesoporous silica nanospheres (MHSs) were successfully synthesized by this method, using triethoxymethylsilane (MTES) as the silica precursor and hexadecyl trimethyl ammonium bromide (CTAB) as the template. SEM and TEM images showed good monodispersity, sphericity, and uniform diameter. Meanwhile, SAXS and N adsorption-desorption measurements demonstrated a highly ordered lamellar mesostructure with a large pore volume. The model drug, curcumin was successfully encapsulated in MHSs for drug delivery testing, and their adsorption capacity was 3.45 mg g, which greatly improved the stability of curcumin. The release time when net release rate of curcumin reached 50% was extended to 6 days.
大规模可控生产均匀单分散球形纳米颗粒的方法一直是近年来科学家们的研究方向之一。在本文中，我们报道了一种共沸蒸馏诱导蒸发自组装方法作为通用方法，以三乙氧基甲基硅烷（MTES）为硅源前驱体，十六烷基三甲基溴化铵（CTAB）为模板，通过该方法成功合成了单分散的疏水有序介孔二氧化硅纳米球（MHSs）。扫描电子显微镜（SEM）和透射电子显微镜（TEM）图像显示出良好的单分散性、球形度和均匀的直径。同时，小角X射线散射（SAXS）和N2吸附-脱附测量表明其具有高度有序的层状介孔结构和大的孔体积。将模型药物姜黄素成功包封在MHSs中进行药物递送测试，其吸附容量为3.45 mg/g，大大提高了姜黄素的稳定性。姜黄素净释放率达到50%时的释放时间延长至6天。
