患者期望与化疗后恶心：一项荟萃分析。
Patient expectancy and post-chemotherapy nausea: a meta-analysis.
机构信息
School of Psychology, A18, University of Sydney, Sydney, NSW, 2006, Australia.
出版信息
Ann Behav Med. 2010 Aug;40(1):3-14. doi: 10.1007/s12160-010-9186-4.
BACKGROUND
Post-chemotherapy nausea remains a significant burden to cancer patients. While some studies indicate that expecting nausea is predictive of experiencing nausea, there are a number of conflicting findings.
PURPOSE
The purpose of this study was to conduct a meta-analytic review to determine the strength of the relationship between expectancy and post-chemotherapy nausea.
METHODS
The findings from 17 relevant studies (n = 2,400) identified through systematic searches of Medline, PsycInfo, and Cinhal were analyzed using a combination of meta-analytic techniques.
RESULTS
Overall, there was a robust positive association between expectancy and post-chemotherapy nausea (ESr = 0.18, equivalent to Cohen's d = 0.35), suggesting that patients with stronger expectancies experience more chemotherapy-induced nausea. Although weaker associations were found in studies employing multivariate analysis, specifically controlling for a history of nausea, and involving breast cancer patients, none of the moderators assessed were statistically significant.
CONCLUSIONS
These findings suggest that patient expectancies may contribute to post-chemotherapy nausea and that expectancy-based manipulations may provide a useful intervention strategy.
背景
化疗后恶心仍然是癌症患者的一个重大负担。虽然一些研究表明，预期恶心是经历恶心的预测因素，但也有一些相互矛盾的发现。
目的
本研究旨在进行荟萃分析，以确定期望与化疗后恶心之间的关系强度。
方法
通过对 Medline、PsycInfo 和 Cinhal 进行系统搜索，确定了 17 项相关研究（n=2400）的结果，并使用荟萃分析技术对其进行了分析。
结果
总体而言，期望与化疗后恶心之间存在强烈的正相关关系（ESr=0.18，相当于 Cohen 的 d=0.35），这表明期望较强的患者经历更多的化疗引起的恶心。尽管在采用多元分析、特别控制恶心史以及涉及乳腺癌患者的研究中发现了较弱的关联，但评估的所有调节剂均无统计学意义。
结论
这些发现表明，患者的期望可能会导致化疗后恶心，并且基于期望的干预可能是一种有用的干预策略。
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