[重型慢性乙型肝炎与HLA-DRB1基因多态性的相关性研究]
[Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism].
作者信息
Liang Hong-xia, Yu Zu-jiang, Jiang He-qing, Zhang Xian-qiang
机构信息
The Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Oct;23(5):364-6.
OBJECTIVE
To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.
METHODS
26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.
RESULTS
The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.
CONCLUSION
HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.
目的
研究HLA - DRB1基因多态性与重度慢性乙型肝炎之间的关联。
方法
采用聚合酶链反应 - 序列特异性引物技术对26例重度慢性乙型肝炎患者进行HLA - DRB1基因多态性检测。运用Microsoft SPSS 13.0软件的卡方检验将结果与45名正常健康人的结果进行比较。
结果
重度慢性乙型肝炎组中HLA - DRB1 * 1301/1302等位基因频率显著高于对照组，而HLA - DRB1 * 1201/1202、1501/1502等位基因频率无显著差异。
结论
HLA - DRB1 * 1301、1302与重度慢性乙型肝炎的易感性密切相关，而HLA - DRB1 * 1201/1202、1501/1502与重度慢性乙型肝炎无关联。
Zotero 插件