Liang Hong-xia, Yu Zu-jiang, Jiang He-qing, Zhang Xian-qiang
The Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Oct;23(5):364-6.
To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.
26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.
The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.
HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.
研究HLA - DRB1基因多态性与重度慢性乙型肝炎之间的关联。
采用聚合酶链反应 - 序列特异性引物技术对26例重度慢性乙型肝炎患者进行HLA - DRB1基因多态性检测。运用Microsoft SPSS 13.0软件的卡方检验将结果与45名正常健康人的结果进行比较。
重度慢性乙型肝炎组中HLA - DRB1 * 1301/1302等位基因频率显著高于对照组，而HLA - DRB1 * 1201/1202、1501/1502等位基因频率无显著差异。
HLA - DRB1 * 1301、1302与重度慢性乙型肝炎的易感性密切相关，而HLA - DRB1 * 1201/1202、1501/1502与重度慢性乙型肝炎无关联。
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