慢性乙型肝炎感染中的HLA II类基因分型
HLA class II genotyping in chronic hepatitis B infection.
作者信息
Amarapurpar D N, Patel N D, Kankonkar S R
机构信息
Department of Gastroenterology, Bombay Hospital and Medical Research Centre, Mumbai.
出版信息
J Assoc Physicians India. 2003 Aug;51:779-81.
OBJECTIVES
To analyze the role of HLA genotypes in persistence of chronic hepatitis B in Western India.
METHODS
HLA genotyping for class II-DR was done in 26 subjects having chronic hepatitis B infection (HBsAg positive) and in 100 healthy controls. Statistics were done using Halden's modification of Woolf's formula.
RESULT
Significant association of chronic hepatitis B infection was found for class II-DR antigens DRB115XX (57.6 vs. 25%) and DRB111XX (23 vs. 4%). DRB1*13XX (0 vs. 19%) was negatively associated with chronic hepatitis B infection.
CONCLUSION
HLA phenotype, which varies with different regions, is one of the factors in persistence of hepatitis B infection. Our study supports negative association of DRB113XX to persistence of HBV. Also there may be role of DRB111XX and DRB1*15XX in persistence of HBV and development of chronic HBV hepatitis.
目的
分析HLA基因型在印度西部慢性乙型肝炎持续感染中的作用。
方法
对26例慢性乙型肝炎感染患者（乙肝表面抗原阳性）和100例健康对照者进行II类-DR的HLA基因分型。使用哈尔登对伍尔夫公式的修正进行统计学分析。
结果
发现II类-DR抗原DRB115XX（57.6%对25%）和DRB111XX（23%对4%）与慢性乙型肝炎感染显著相关。DRB1*13XX（0对19%）与慢性乙型肝炎感染呈负相关。
结论
HLA表型因不同地区而异，是乙型肝炎感染持续存在的因素之一。我们的研究支持DRB113XX与乙肝病毒持续感染呈负相关。此外，DRB111XX和DRB1*15XX可能在乙肝病毒持续感染及慢性乙肝肝炎的发生中起作用。
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