Liang Hong-Xia, Yu Zu-Jiang, Jiang He-Qing
Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Aug;23(4):302-3.
To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.
HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.
The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.
HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.
探讨慢性乙型肝炎肝硬化与HLA - DRB1 * 1301、1302基因之间的关联。
采用聚合酶链反应/序列特异性引物（PCR - SSP）技术分析27例慢性乙型肝炎肝硬化患者和30例慢性乙型肝炎患者的HLA - DRB1 * 1301、1302等位基因。
慢性乙型肝炎肝硬化组中HLA - DRB1 * 1301、1302等位基因频率明显高于慢性乙型肝炎组。
HLA - DRB1 * 1301、1302与慢性肝炎肝硬化的易感性密切相关。
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