六组分反应通过顺序一锅 Ugi/Heck 碳环化/Sonogashira/亲核加成反应立体选择性合成 3-芳亚甲基-2-氧代吲哚。

Six-component reactions for the stereoselective synthesis of 3-arylidene-2-oxindoles via sequential one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition.

机构信息

Peptide Chemistry Research Group, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.

出版信息

J Org Chem. 2010 May 7;75(9):2806-12. doi: 10.1021/jo902713x.

PMID:20387848

Abstract

An efficient palladium-catalyzed protocol for the synthesis of 3-arylidene-2-oxindoles has been developed. In this approach, a sequential one-pot six-component reaction via Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition was used for the synthesis of the desired skeleton.

摘要

一种高效的钯催化合成 3-芳亚甲基-2-氧吲哚的方法已经被开发出来。在这种方法中，通过 Ugi/Heck 环化/Sonogashira/亲核加成的顺序一锅六组分反应被用于合成目标骨架。