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从 3-甲酰基色酮、二烷基丙炔二羧酸酯和伯胺出发，高效、简便地合成了 3-氨基-5-色烯基丁烯内酯。

An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

机构信息

Peptide Chemistry Research Center, KN Toosi University of Technology, Tehran, Iran.

出版信息

Mol Divers. 2013 Feb;17(1):55-61. doi: 10.1007/s11030-013-9423-4. Epub 2013 Jan 23.

DOI:10.1007/s11030-013-9423-4
PMID:23341007
Abstract

A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of POCl(3) was used as a highly efficient and practical approach for the synthesis of 3-amino-5-chromenyl-butenolides. High yields and high bond forming efficiency, and simple operations are the advantages of this method. Graphical abstract.

摘要

在三氯化磷（POCl(3)）存在下，3-甲酰基色酮、二烷基乙酰基丙二酸盐和异氰化物的三组分反应被用作合成 3-氨基-5-色烯基丁烯内酯的高效、实用方法。该方法的优点是产率高、键形成效率高、操作简单。

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3
The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: access to chiral γ-butenolides and glycerol derivatives.
呋喃酮与α-酮酯的直接不对称乙烯基烯醇醛反应：合成手性γ-丁烯内酯和甘油衍生物
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Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.3,4-二氯-5-（ω-羟烷基氨基）-2（5H）-呋喃酮的合成及初步生物活性测定。
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