阳离子 Pd(II)催化的 2-芳基乙炔基苯胺和醛的串联反应：取代 3-羟甲基吲哚的高效合成。
Cationic Pd(II)-catalyzed tandem reaction of 2-arylethynylanilines and aldehydes: an efficient synthesis of substituted 3-hydroxymethyl indoles.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Org Lett. 2010 Aug 6;12(15):3336-9. doi: 10.1021/ol1011086.
PMID:20670002
Abstract
An efficient cationic palladium(II)-catalyzed synthesis of substituted 3-hydroxymethylindoles from readily accessible starting materials is developed. This tandem reaction involves an intramolecular aminopalladation of an alkyne and an addition to the carbonyl group to quench the carbon-palladium bond to complete the catalytic cycle without the necessity of a redox system.
摘要
开发了一种从易得起始原料高效合成取代 3-羟甲基吲哚的阳离子钯（II）催化方法。该串联反应涉及炔烃的分子内氨钯化和与羰基的加成，以淬灭碳-钯键，从而完成催化循环，而无需氧化还原体系。
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