（+）-Complanadine A 的合成，一种诱导神经营养因子分泌的物质。
Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion.
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
J Am Chem Soc. 2010 May 5;132(17):5924-5. doi: 10.1021/ja101956x.
PMID:20387896
Abstract
A total synthesis of the Lycopodium alkaloid (+)-complanadine A is described. Complanadine A has been shown to induce the secretion of neurotrophic factors from 1321N1 cells, promoting the differentiation of PC-12 cells. The use of a simplifying metal mediated [2+2+2] + [2+2+2] sequence using a silyl-substituted diyne and 2 equiv of the corresponding alkyne-nitrile has provided rapid access to the natural product.
摘要
本文描述了石松生物碱（+）-金钗石斛宁 A 的全合成。研究表明，金钗石斛宁 A 可诱导 1321N1 细胞分泌神经营养因子，促进 PC-12 细胞分化。使用简化的金属介导 [2+2+2]+[2+2+2] 序列，使用硅取代的二炔和 2 当量的相应炔基腈，为快速获得天然产物提供了途径。
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