Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, 6202 AZ Maastricht, the Netherlands.
Pharmacoeconomics. 2010;28(6):507-20. doi: 10.2165/11532240-000000000-00000.
Nowadays, an increasing number of discrete-choice experiments (DCEs) incorporate cost as an attribute. However, the inclusion of a cost attribute, particularly within collectively funded healthcare systems, can be challenging because health services or goods are generally not traded in a market situation and individuals are not used to paying for a service or a good at the point of consumption.
To examine whether the inclusion of a cost attribute in a DCE results in different preferences regarding a surgical treatment for primary basal cell carcinoma (BCC) compared with a DCE without a cost attribute.
A randomized study was performed in which the impact of a cost attribute on the general public's preferences for a surgical treatment (Mohs micrographic surgery [MMS] or standard excision [SE]) to remove BCC was examined. This was done by comparing the outcomes of two DCEs, one with a cost attribute (DCE_cost) and one without (DCE_nocost). Six attributes (recurrence, re-excision, travel time, surgical time, waiting time for surgical results, costs) and their levels were selected, based on results of a clinical trial, a cost-effectiveness study, a review and a focus group of patients who had recently received treatment for BCC. Outcomes of both DCEs were compared in terms of theoretical validity, relative importance of the attributes and the rank order of preferences.
A total of 615 respondents (n = 303 for DCE_nocost; n = 312 for DCE_cost) were interviewed by telephone. This gave an overall response rate of 38%. Respondents in DCE_nocost preferred a surgical treatment with a lower probability of recurrence, lower surgery time, lower waiting time and no risk for a re-excision. Respondents in DCE_cost showed the same preferences, but also preferred a treatment with less travel time and lower costs. Overall, respondents in both DCEs showed the same preference for a surgical treatment: MMS was preferred over SE.
Results suggest that, in this population, the inclusion of a cost attribute in a DCE leads to the same preference regarding a surgical treatment to remove BCC as a DCE without a cost attribute. However, further research in different settings is needed to confirm these findings.
如今,越来越多的离散选择实验(DCE)将成本作为一个属性纳入其中。然而,在共同资助的医疗保健系统中纳入成本属性可能具有挑战性,因为健康服务或商品通常不在市场环境中交易,并且个人不习惯在消费时为服务或商品付费。
检查在 DCE 中纳入成本属性是否会导致对原发性基底细胞癌(BCC)手术治疗的偏好与不包含成本属性的 DCE 不同。
进行了一项随机研究,其中检查了成本属性对一般公众对 BCC 手术治疗(Mohs 显微外科手术[MMS]或标准切除术[SE])偏好的影响。这是通过比较两个 DCE 的结果来完成的,一个带有成本属性(DCE_cost),一个没有(DCE_nocost)。基于临床试验、成本效益研究、综述和一组最近接受 BCC 治疗的患者焦点小组的结果,选择了 6 个属性(复发、再次切除、旅行时间、手术时间、手术结果等待时间、成本)及其水平。比较了两个 DCE 的结果,包括理论有效性、属性的相对重要性和偏好的等级顺序。
通过电话采访了 615 名受访者(DCE_nocost 组 n = 303;DCE_cost 组 n = 312)。这给出了 38%的总回复率。DCE_nocost 中的受访者更喜欢复发概率较低、手术时间较短、等待时间较短且无再次切除风险的手术治疗。DCE_cost 中的受访者也表现出同样的偏好,但也更喜欢旅行时间和成本较低的治疗方法。总体而言,两个 DCE 中的受访者对 BCC 去除的手术治疗有相同的偏好:MMS 优先于 SE。
结果表明,在该人群中,DCE 中包含成本属性会导致与不包含成本属性的 DCE 相同的 BCC 手术治疗偏好。然而,需要在不同环境中进行进一步的研究来证实这些发现。