甲基（5-（2-噻吩基羰基）-1H-苯并咪唑-2-基）氨基甲酸酯（R17934），一种合成的微管抑制剂，在体外可防止恶性侵袭。
Methyl (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl) carbamate, (R17934), a synthetic microtubule inhibitor, prevents malignant invasion in vitro.
作者信息
Mareel M, de Brabander M
出版信息
Oncology. 1978;35(1):5-7. doi: 10.1159/000225246.
The effect of malignant invasion of methyl (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl) carbamate, (R17934), a microtubule inhibitor, was examined in organotypical co-cultures of mouse sarcoma virus transformed cells (MO4) and embryonic chick tissues. In contrast with control cultures, 1 microgram/ml R17934 prevented invasion of MO4 cells into the host tissue. Since mitostatic doses of 5-fluorouracil did not inhibit invasion, we presumed that the anti-invasive properties of R17934 were correlated with a loss of microtubule mediated directional cell migration.
对微管抑制剂氨基甲酸甲酯（5-（2-噻吩基羰基）-1H-苯并咪唑-2-基）（R17934）的恶性侵袭作用，在小鼠肉瘤病毒转化细胞（MO4）与胚胎鸡组织的器官型共培养物中进行了检测。与对照培养物相比，1微克/毫升的R17934可阻止MO4细胞侵袭宿主组织。由于5-氟尿嘧啶的有丝分裂抑制剂量并不抑制侵袭，我们推测R17934的抗侵袭特性与微管介导的定向细胞迁移丧失有关。
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