机械控制组织和器官发育。
Mechanical control of tissue and organ development.
机构信息
Vascular Biology Program, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Development. 2010 May;137(9):1407-20. doi: 10.1242/dev.024166.
Abstract
Many genes and molecules that drive tissue patterning during organogenesis and tissue regeneration have been discovered. Yet, we still lack a full understanding of how these chemical cues induce the formation of living tissues with their unique shapes and material properties. Here, we review work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.
摘要
许多在器官发生和组织再生过程中驱动组织模式形成的基因和分子已经被发现。然而，我们仍然缺乏对这些化学信号如何诱导具有独特形状和材料特性的活体组织形成的全面理解。在这里，我们回顾了基于物理、工程和生物学融合的工作，这些工作表明，活细胞产生的机械力与基因和化学信号一样，对于胚胎发育、形态发生和组织模式形成的控制至关重要。
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