Wegener S, Bruhn P, Keysser M
Institut für Transfusionsmedizin, Bezirkskrankenhauses Rostock.
Z Gesamte Inn Med. 1991 Jan-Feb;46(1-2):23-6.
109 patients with rheumatoid arthritis (RA) from the north of the GDR were HLA typed and the antigen frequencies compared with those of a control group. Even in our patients the HLA-DR4 association was demonstrable. But in all studies DR4 association is not strong enough for taking HLA typing as a diagnostic test for RA. There was an immunogenetic heterogeneity in correlation to side effects of therapy with sodium aurothiomalate or D-penicillamine. HLA-DR5 was significantly increased in patients with side effects in comparison to patients without side effects in therapy. Before recommending HLA-DR typing for selection of high risk patients in D-penicillamine therapy these results should be proven in a large patient group or in a second study.
对来自民主德国北部的109例类风湿性关节炎（RA）患者进行了HLA分型，并将抗原频率与对照组进行了比较。即使在我们的患者中，HLA - DR4相关性也是可证实的。但在所有研究中，DR4相关性不足以将HLA分型作为RA的诊断测试。在与金硫代苹果酸钠或D - 青霉胺治疗的副作用相关性方面存在免疫遗传异质性。与治疗中无副作用的患者相比，有副作用的患者中HLA - DR5显著增加。在推荐将HLA - DR分型用于选择D - 青霉胺治疗的高危患者之前，这些结果应在大量患者群体中或第二项研究中得到证实。
