Zarnowski H, Mierau R, Werdier D, Antons M, Genth E, Hartl P W
J Rheumatol. 1986 Oct;13(5):858-63.
Ninety-four patients with seropositive rheumatoid arthritis (RA) were typed for HLA-A, B, C and DR antigens and for immunoglobulin G (Gm) allotypes. Isolated IgG from patient serum was used to avoid interference of IgM rheumatoid factor (RF) with Gm typing in sera with high IgM-RF titer. Besides the association of seropositive RA with the antigen DR4 and an earlier disease onset in DR3/DR4 heterozygotes, we found the uncommon Gm phenotype Gm(1,2;21) significantly more often in our patient group than in healthy controls. Combination of HLA-DR and Gm data shows that individuals with both DR4 and Gm(1,2;21) are at a particularly high disease risk.
对94例血清反应阳性的类风湿性关节炎（RA）患者进行了HLA - A、B、C和DR抗原以及免疫球蛋白G（Gm）同种异型分型。使用从患者血清中分离出的IgG，以避免在IgM类风湿因子（RF）滴度高的血清中，IgM类风湿因子对Gm分型产生干扰。除了血清反应阳性的RA与抗原DR4相关，以及DR3/DR4杂合子发病较早之外，我们发现患者组中罕见的Gm表型Gm(1,2;21)比健康对照组更为常见。HLA - DR和Gm数据的组合显示，同时具有DR4和Gm(1,2;21)的个体疾病风险特别高。
