Kvale Elizabeth A, Woodby Lesa, Williams Beverly Rosa
Birmingham/Atlanta Geriatric Research Education and Clinical Center, AL, USA.
Am J Hosp Palliat Care. 2010 Nov;27(7):474-81. doi: 10.1177/1049909110365072. Epub 2010 Apr 13.
This article explores the experiences of older patients with cancer in phase 1 clinical trials. Conducting a case series of face-to-face, in-depth, open-ended interviews and using qualitative methods of analysis, we find that the psychosocial process of social comparison is relevant for understanding older adults' phase 1 clinical trial participation. Social comparison influences decisions to enroll in a phase 1 clinical trial, shapes perceptions of supportive care needs, and encourages the utilization of hope. Additional research should develop strategies for addressing supportive care needs among this patient cohort whose use of social comparison can inhibit articulation of pain, suffering, and symptom burden as well as use of informal support systems.
本文探讨了老年癌症患者在1期临床试验中的经历。通过开展一系列面对面、深入、开放式访谈并运用定性分析方法，我们发现社会比较的心理社会过程与理解老年人参与1期临床试验相关。社会比较影响参与1期临床试验的决策，塑造对支持性护理需求的认知，并激发希望的运用。进一步的研究应制定策略，以满足这一患者群体的支持性护理需求，因为他们进行社会比较可能会抑制对疼痛、痛苦和症状负担的表达，以及对非正式支持系统的使用。
