Schutta K M, Burnett C B
Hematology/Oncology Department, Georgetown University Medical Center, Washington, DC, USA.
Oncol Nurs Forum. 2000 Oct;27(9):1435-8.
PURPOSE/OBJECTIVES: To explore factors that influence an individual's decision to participate in phase I cancer clinical trials.
Exploratory, descriptive, and qualitative study.
Outpatient oncology clinic of a comprehensive cancer center in an urban setting.
22 patients with cancer who had been asked at some point during their treatment to participate in a phase I cancer clinical trial were invited to participate in a focus group. Eight patients participated.
Two focus groups were conducted.
Factors that influenced patients' decisions to participate in a phase I cancer clinical trial.
Participants expressed that hope for a cure and trusting the oncologist's advice were the primary factors that influenced their decisions to participate in phase I research. The majority expressed surprise that anyone would participate in an experimental study for altruistic reasons.
Patients choose to hope for some personal benefit from their participation in phase I clinical trials even though they realized that is not the purpose or goal of the trial.
Nurses are in an ideal position to offer information to individuals who are deciding whether to participate in a phase I cancer clinical trial. However, most nurses are not seizing this opportunity. Patients are unable to describe nurses' impact on their decision to enter a phase I cancer clinical trial.
目的/目标：探讨影响个体参与I期癌症临床试验决策的因素。
探索性、描述性和定性研究。
城市环境中一家综合癌症中心的门诊肿瘤诊所。
22名癌症患者在治疗期间的某个时间点被邀请参与I期癌症临床试验，他们受邀参加焦点小组。8名患者参与。
进行了两个焦点小组。
影响患者参与I期癌症临床试验决策的因素。
参与者表示，治愈的希望和信任肿瘤学家的建议是影响他们参与I期研究决策的主要因素。大多数人对有人会出于利他原因参与实验研究表示惊讶。
患者选择希望从参与I期临床试验中获得一些个人益处，尽管他们意识到这不是试验的目的或目标。
护士处于向正在决定是否参与I期癌症临床试验的个人提供信息的理想位置。然而，大多数护士没有抓住这个机会。患者无法描述护士对他们参与I期癌症临床试验决策的影响。
