Yamada M, Zurbriggen A, Fujinami R S
Department of Pathology, University of California, San Diego, La Jolla 92093.
Adv Virus Res. 1991;39:291-320. doi: 10.1016/s0065-3527(08)60798-8.
Theiler's murine encephalomyelitis virus belongs to the family of picornaviridae. Picornaviruses are small ( “pico”), phylogenetically related RNA viruses. Based on different biochemical and biophysical characteristics picornaviruses are subdivided into four groups: enteroaphthovirus (foot-and-mouth disease virus), cardiovirus [encephalomyocarditis virus (EMCV), Mengo virus], and rhinovirus (human rhinovirus). Theiler's murine encephalomyelitis virus was originally classified among the picornaviridae as an enterovirus because of its biological similarities with poliovirus. Further comparison of the complete genome of TMEV BeAn 8386 strain identifies remarkable similarities at the level of nucleotides and predicted amino acids between BeAn and the cardioviruses EMCV and Mengo virus. Theiler's murine encephalomyelitis virus is a single-stranded nonenveloped RNA virus. The viral RNA is of positive sense, having the same polarity as mRNA. Viral mRNA lacks the cap structure found at the 5’ end of almost all eukaryotic mRNAs.
泰勒氏鼠脑脊髓炎病毒属于小核糖核酸病毒科。小核糖核酸病毒是小型的(“微小”)、在系统发育上相关的RNA病毒。基于不同的生化和生物物理特性,小核糖核酸病毒可分为四组:肠道口疮病毒(口蹄疫病毒)、心病毒[脑心肌炎病毒(EMCV)、门戈病毒]和鼻病毒(人鼻病毒)。泰勒氏鼠脑脊髓炎病毒最初因其与脊髓灰质炎病毒的生物学相似性而被归类为小核糖核酸病毒科中的肠道病毒。对TMEV BeAn 8386株完整基因组的进一步比较发现,BeAn与心病毒EMCV和门戈病毒在核苷酸水平和预测的氨基酸水平上存在显著相似性。泰勒氏鼠脑脊髓炎病毒是一种单链无包膜RNA病毒。病毒RNA为正链,与mRNA具有相同的极性。病毒mRNA缺乏几乎所有真核mRNA 5’端发现的帽结构。