Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Rheumatol Int. 2011 Oct;31(10):1321-1324. doi: 10.1007/s00296-010-1479-1.
CD28 is one of the main activator receptors involved in systemic lupus erythematosus (SLE) pathogenesis, and its expression and serum levels are significantly higher in patients with SLE and other autoimmune diseases than in healthy controls (HC). However, it is unknown whether this increase is associated with specific organ damage. Therefore, our objective was to measure the CD28 levels in serum from SLE and HC groups to confirm the CD28 serum levels increase, as reported previously, and to determine whether this increase was associated with specific organ activity and the SLE Disease Activity Index (SLEDAI). Forty SLE patients and 40 matched HC were included, and the age, disease duration, SLEDAI and Mexican SLEDAI were recorded for the SLE group. CD28 serum levels were measured by ELISA. There was a statistically significant increase in the CD28 serum levels of SLE patients compared to controls (p = 0.039); however, we did not find any significant correlation with disease activity indices or organ involvement, although we found a significant but low correlation with C3. Our results and a review of the literature suggest that the increase in CD28 serum levels may be the result of CD28 gene overexpression, which could be related to the decrease in CD28+ T cells, T-cell hyporesponsiveness and immune impairment that occurs in SLE.
CD28 是系统性红斑狼疮 (SLE) 发病机制中主要的激活受体之一，其在 SLE 和其他自身免疫性疾病患者中的表达和血清水平明显高于健康对照组 (HC)。然而，尚不清楚这种增加是否与特定的器官损伤有关。因此，我们的目的是测量 SLE 和 HC 组血清中的 CD28 水平，以确认以前报道的 CD28 血清水平增加，并确定这种增加是否与特定的器官活性和 SLE 疾病活动指数 (SLEDAI) 相关。纳入了 40 名 SLE 患者和 40 名匹配的 HC，记录了 SLE 组的年龄、疾病持续时间、SLEDAI 和墨西哥 SLEDAI。通过 ELISA 测量 CD28 血清水平。与对照组相比，SLE 患者的 CD28 血清水平有统计学显著升高 (p = 0.039)；然而，我们没有发现与疾病活动指数或器官受累有任何显著相关性，尽管我们发现与 C3 有显著但低度的相关性。我们的结果和文献复习表明，CD28 血清水平的增加可能是 CD28 基因过度表达的结果，这可能与 SLE 中发生的 CD28+T 细胞减少、T 细胞低反应性和免疫受损有关。
