来自海洋真菌青霉属的三种新化合物

Three new compounds from the marine fungus Penicillium sp.

作者信息

Wu Hong-Hua, Tian Li, Feng Bao-Min, Li Zhi-Feng, Zhang Qi-Hui, Pei Yue-Hu

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

出版信息

J Asian Nat Prod Res. 2010 Jan;12(1):15-9. doi: 10.1080/10286020903442020.

DOI:10.1080/10286020903442020

PMID:20390738

Abstract

Continuous research on the ethyl acetate extract of the fermentation broth of the marine fungus Y26-02 (Penicillium sp.) led to the purification of one known and three new compounds. Their structures were elucidated, respectively, as butyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (1), 4-hydroxyphenethyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (2), 3-hydroxybenzyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (3), and desoxypatulinic acid (4) on the basis of their spectroscopic and physico-chemical properties.

摘要

对海洋真菌Y26 - 02（青霉属）发酵液乙酸乙酯提取物的持续研究，使得一种已知化合物和三种新化合物得以纯化。根据它们的光谱和物理化学性质，其结构分别被鉴定为2-(4-氧代-5,6-二氢-2H-吡喃-3-基)乙酸丁酯(1)、2-(4-氧代-5,6-二氢-2H-吡喃-3-基)乙酸4-羟基苯乙酯(2)、2-(4-氧代-5,6-二氢-2H-吡喃-3-基)乙酸3-羟基苄酯(3)和脱氧展青霉素(4)。