从海洋真菌灰黄青霉Y19 - 07的发酵液中分离出的两种新化合物。

Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07.

作者信息

Wang Ya-Nan, Tian Li, Hua Hui-Ming, Lu Xuan, Sun Sha, Wu Hong-Hua, Pei Yue-Hu

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

出版信息

J Asian Nat Prod Res. 2009 Nov;11(11):912-7. doi: 10.1080/10286020903219923.

DOI:10.1080/10286020903219923

PMID:20183253

Abstract

Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC(50) value of 64.5 microM against human HL-60 cancer cells.

摘要

从海洋真菌灰黄青霉Y19 - 07发酵液的乙酸乙酯提取物中分离出两种新化合物，4 - 羟基苯乙基甲基琥珀酸酯（1）和4 - 羟基苯乙基2 -（4 - 羟基苯基）乙酸酯（2）。本研究还获得了五种已知化合物。通过一维和二维核磁共振光谱以及质谱对新化合物的结构进行了阐明。通过光谱分析对所有分离物针对2,2 - 二苯基 - 1 - 苦基肼自由基的清除特性进行了评估。此外，在两种新化合物对HL - 60和PC - 3前列腺癌细胞系的细胞毒性试验中，化合物2表现出潜在活性，对人HL - 60癌细胞的IC(50)值为64.5微摩尔。