从海洋来源真菌青霉属菌株F11中分离得到的两种新化合物。

Two new compounds from marine-derived fungus Penicillium sp. F11.

作者信息

Zhuang Ping, Tang Xi-Xiang, Yi Zhi-Wei, Qiu Ying-Kun, Wu Zhen

机构信息

Medical College, Xiamen University, Xiamen, 361005, China.

出版信息

J Asian Nat Prod Res. 2012;14(3):197-203. doi: 10.1080/10286020.2011.634279. Epub 2012 Jan 16.

DOI:10.1080/10286020.2011.634279

PMID:22248032

Abstract

Two new compounds, penicillone A (1) and penicillactam (2), were isolated together with 17 known compounds from a marine-derived fungus Penicillium sp. F11. The structures of the new compounds as well as a firstly literatural reported known compound (3) were assigned by spectroscopic methods including 1D/2D NMR and MS analysis techniques. Their cytotoxicities against HT1080, Cne2, and Bel7402 cell lines were also evaluated.

摘要

从海洋来源的青霉菌Penicillium sp. F11中分离出两种新化合物，青霉酮A（1）和青霉内酰胺（2），同时还分离出17种已知化合物。通过包括一维/二维核磁共振和质谱分析技术在内的光谱方法确定了新化合物以及首次文献报道的已知化合物（3）的结构。还评估了它们对HT1080、Cne2和Bel7402细胞系的细胞毒性。