Department of Clinical Physiopathology, University of Florence, Florence, Italy.
Eur J Nucl Med Mol Imaging. 2010 Aug;37(9):1722-9. doi: 10.1007/s00259-010-1444-y.
Perfusion gated single photon emission computed tomography (SPECT) can assess with good reproducibility left ventricular (LV) volumes and ejection fraction (EF). Whether this reproducibility is maintained in long-term follow-up is unknown.
We compared LV end-diastolic (ED) and end-systolic (ES) volumes (V) as well as EF calculated using gated SPECT and QGS software in 103 coronary artery disease patients studied twice at > 1-year interval because of standard clinical indications. Patients were divided into two groups: (A) 67 patients without major clinical changes and with stable resting perfusion and (B) 36 with modified clinical status or resting perfusion.
The relationship between gated SPECT 2 EF (=y) and gated SPECT 1 EF (=x) was for group A: y=0.91 x + 5.34, r=0.92, p<0.0001, SEE=4 and for group B: y=0.67 x + 13.6, r=0.63, p<0.0001, SEE=10. The 95% limit of agreement was 8 EF units for group A and 20.6 EF units for group B. For EDV, the 95% limit of agreement was 22 ml for group A and 52 ml for group B. For ESV, the 95% limit of agreement was 13 ml for group A and 44 ml for group B.
In stable patients with an unmodified resting perfusion pattern the functional parameters derived from perfusion gated SPECT have good reproducibility even after a prolonged time interval. This supports the value of gated SPECT for serial evaluations of LV function.
灌注门控单光子发射计算机断层扫描（SPECT）可以很好地评估左心室（LV）容积和射血分数（EF），且重复性良好。但目前尚不清楚这种重复性是否能维持长期随访。
我们比较了 103 例因标准临床指征行两次间隔> 1 年的冠状动脉疾病患者的门控 SPECT 和 QGS 软件计算的 LV 舒张末期（ED）和收缩末期（ES）容积（V）和 EF。患者分为两组：（A）67 例无重大临床变化且静息灌注稳定；（B）36 例临床状况或静息灌注有改变。
A 组门控 SPECT 2 EF（=y）与门控 SPECT 1 EF（=x）的关系为：y=0.91 x + 5.34，r=0.92，p<0.0001，SEE=4；B 组为：y=0.67 x + 13.6，r=0.63，p<0.0001，SEE=10。A 组和 B 组的 95%一致性界限分别为 8 EF 单位和 20.6 EF 单位。EDV 的 95%一致性界限分别为 22 ml 和 52 ml。ESV 的 95%一致性界限分别为 13 ml 和 44 ml。
在静息灌注模式无改变且稳定的患者中，即使经过较长时间间隔，来自灌注门控 SPECT 的功能参数也具有良好的可重复性。这支持了门控 SPECT 用于 LV 功能的连续评估。
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