FOM Institute AMOLF, Biosurface Spectroscopy, Science Park 104, 1098 XG Amsterdam, The Netherlands.
Chemphyschem. 2010 May 17;11(7):1365-73. doi: 10.1002/cphc.200900975.
The use of an illuminated scanning probe tip to greatly enhance Raman scattering from the sample underneath the tip is one of the most intriguing developments in optical spectroscopy, and the steeply increasing number of publications per year shows that chemists, physicists and biologists alike recognize the importance and great potential of this technique. With tip-enhanced Raman spectroscopy (TERS), one of the main goals in surface science has been achieved, namely the combination of scanning probe microscopy and optical spectroscopy such as Raman spectroscopy. Important here is the use of the tip as an optical antenna to substantially increase the emitted radiation and to simultaneously improve the optical resolution much beyond the Abbe diffraction limit. This permits the correlation of topographic and chemical information of the same surface region. The synergy of detailed insight in morphology and the chemical nature of the target species facilitates data interpretation significantly and enables characterization of interfaces at the nanometer scale. A wide variety of substrates and sample molecules have been studied with TERS since the first publication of tip-enhanced Raman spectra, and the technique has reached a first level of maturity on its 10th birthday, with TERS applications extending into various research fields from surface chemistry over biology to nanoscale physics.
利用照明扫描探针尖端极大地增强探针下方样品的拉曼散射，是光学光谱学中最引人入胜的发展之一。每年发表的论文数量急剧增加，表明化学、物理和生物学家都认识到这项技术的重要性和巨大潜力。通过针尖增强拉曼光谱（TERS），表面科学的主要目标之一已经实现，即将扫描探针显微镜和光学光谱学（如拉曼光谱学）结合起来。这里的一个重要特点是使用尖端作为光学天线，以大幅增加发射辐射，并同时大大提高光学分辨率，超出阿贝衍射极限。这使得同一表面区域的形貌和化学信息的相关性成为可能。目标物种的形态和化学性质的详细洞察力的协同作用大大促进了数据解释，并能够在纳米尺度上对界面进行表征。自首次发表针尖增强拉曼光谱以来，已经对各种基底和样品分子进行了 TERS 研究，该技术在其 10 岁生日时达到了第一个成熟水平，TERS 应用从表面化学扩展到生物学再到纳米级物理学等各个研究领域。
