低剂量经皮睾酮增强疗法可改善女性的抑郁严重程度。
Low-dose transdermal testosterone augmentation therapy improves depression severity in women.
机构信息
Neurendocrine Research Program in Women's Health, Neuendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
出版信息
CNS Spectr. 2009 Dec;14(12):688-94. doi: 10.1017/s1092852900023944.
BACKGROUND
Inadequate response to antidepressant monotherapy in women with major depressive disorder is common. Testosterone administration has been shown to be an effective augmentation therapy in depressed hypogonadal men with selective serotonin reuptake inhibitor-resistant depression. However, the effects of low-dose testosterone as augmentation therapy in women with treatment-resistant depression have not been studied.
METHODS
Low-dose transdermal testosterone (300 mcg/day, Intrinsa, Procter and Gamble Pharmaceuticals) was administered to nine women with treatment-resistant depression in an 8 week open-label pilot protocol.
RESULTS
There was a statistically significant improvement in mean Montgomery-Asberg Depression Rating Scale (MADRS) scores at 2 weeks, sustained through the 8 week period. Two-thirds of subjects achieved a response to the treatment (decrease in MADRS score of 250%) and 33% achieved remission (final MADRS score <10) after 8 weeks of therapy. Mean levels of fatigue, as measured by the MADRS lassitude item, significantly decreased at all time points with a mean 38% decrease from baseline to 8 weeks.
CONCLUSION
These preliminary pilot data suggest that low-dose transdermal testosterone may be an effective augmentation therapy in women with treatment-resistant depression. Further studies are warranted. CNS Spectr. 2009;14(12):688-694
背景
在患有重度抑郁症的女性中，抗抑郁药单药治疗反应不足很常见。雄激素治疗已被证明对选择性 5-羟色胺再摄取抑制剂抵抗性抑郁的低促性腺激素男性是一种有效的增效治疗方法。然而，低剂量睾酮作为增效治疗在治疗抵抗性抑郁症女性中的作用尚未得到研究。
方法
在一项为期 8 周的开放性先导方案中，9 名治疗抵抗性抑郁症女性接受了低剂量经皮睾酮（300 mcg/天，Intrinsa，宝洁制药）治疗。
结果
在第 2 周时，平均蒙哥马利-阿斯伯格抑郁评定量表（MADRS）评分有统计学意义的改善，持续到 8 周。三分之二的患者对治疗有反应（MADRS 评分下降 250%），33%的患者在 8 周治疗后达到缓解（最终 MADRS 评分<10）。疲劳的平均水平，用 MADRS 倦怠项目衡量，在所有时间点均显著下降，从基线到 8 周平均下降 38%。
结论
这些初步的先导数据表明，低剂量经皮睾酮可能是治疗抵抗性抑郁症女性的有效增效治疗方法。需要进一步的研究。中枢神经系统光谱。2009;14(12):688-694
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