Cuvas Ozgun, Basar Hulya, Yeygel Aydan, Turkyilmaz Esra, Sunay Mehmet Melih
Department of Anesthesiology and Intensive Care Medicine, Ankara Training and Research Hospital, Ulucanlar, Ankara, Turkey.
Middle East J Anaesthesiol. 2010 Feb;20(4):547-52.
The objective ofthe present study was double fold; to compare the characteristics of spinal blocks produced by 0.5% levobupivacaine with and without fentanyl in transurethral resection and to test the hypothesis that, fentanyl added to levobupivacaine, may be used as an alternative to pure levobupivacaine solution, in spinal anesthesia.
Forty males, aged >60 years, ASA I-III patients scheduled for elective transurethral resection were included in a prospective, randomized, double-blinded study. Following a spinal tap, intrathecal injection in Group L (n=20), 2.5 mL of 0.5% levobupivacaine and in Group LF (n=20), 2.2 mL of 0.5% levobupivacaine with fentanyl 15 microg (0.3 mL) was performed. The characteristics of sensory and motor block, hemodynamic data, side effects, patient and surgeon satisfaction were recorded. Patients were observed until the level of sensory block was S1 and the Bromage score was 0.
There were no significant differences between the two groups forpatient demographic, intraoperative, hemodynamic parameters, side effects and satisfaction. The highest level of sensory block was T9 in the Group L, and T6 in the Group LF (p = 0.001). Duration of motor block was shorter in Group LF than in Group L (291.00 +/- 81.08 min in Group L; 213.75 +/- 59.49 min in Group LF) (p = 0.001).
Both regimes are effective, and the addition of fentanyl to levobupivacaine may offers the advantage of shorter duration of motor block and may be used as an alternative to pure levobupivacaine solution in spinal anesthesia, for transurethral resections.
本研究目的有两个;一是比较在经尿道前列腺切除术中,0.5%左旋布比卡因加与不加芬太尼所产生的脊髓阻滞特征,二是检验以下假设:在脊髓麻醉中,左旋布比卡因中添加芬太尼可作为单纯左旋布比卡因溶液的替代方案。
40例年龄大于60岁、ASA分级I-III级、计划行择期经尿道前列腺切除术的男性患者纳入一项前瞻性、随机、双盲研究。在进行脊髓穿刺后,L组(n=20)鞘内注射2.5 mL 0.5%左旋布比卡因,LF组(n=20)鞘内注射2.2 mL含15 μg芬太尼(0.3 mL)的0.5%左旋布比卡因。记录感觉和运动阻滞特征、血流动力学数据、副作用、患者及外科医生满意度。观察患者直至感觉阻滞平面达S1且布罗麻评分变为0。
两组患者的人口统计学、术中、血流动力学参数、副作用及满意度方面均无显著差异。L组感觉阻滞最高平面为T9,LF组为T6(p = 0.001)。LF组运动阻滞持续时间短于L组(L组为291.00±81.08分钟;LF组为213.75±59.49分钟)(p = 0.001)。
两种方案均有效,左旋布比卡因中添加芬太尼可能具有运动阻滞持续时间较短的优势,在经尿道前列腺切除术的脊髓麻醉中可作为单纯左旋布比卡因溶液的替代方案。