Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Am J Clin Dermatol. 2010;11(5):363-6. doi: 10.2165/11533200-000000000-00000.
Painful granulomatous lesions appeared on the face of a 36-year-old man with myelodysplastic syndrome. Skin biopsy revealed chronic inflammatory granuloma. Bacterial cultures of the lesions and blood indicated the same unknown Gram-negative rod bacterium. The 16S ribosomal RNA sequence of the unknown bacterium yielded Phenylobacterium. Thus, we diagnosed cutaneous infectious granuloma caused by Phenylobacterium and myelodysplastic syndrome/refractory cytopenia with multi-lineage dysplasia. After treatment with combined antibacterials that were selected based on the tests for drug sensitivity, the lesions disappeared with only scars remaining and without any signs of relapse after 1 year. This is the first case report of cutaneous infectious granuloma caused by Phenylobacterium.
一位 36 岁患有骨髓增生异常综合征的男性患者面部出现疼痛性肉芽肿性病变。皮肤活检显示慢性炎症性肉芽肿。病变和血液的细菌培养均提示同一种未知革兰氏阴性杆状菌。该未知细菌的 16S 核糖体 RNA 序列为苯基杆菌属。因此，我们诊断为骨髓增生异常综合征/难治性血细胞减少伴多系发育异常引起的皮肤感染性肉芽肿。根据药敏试验选择联合抗菌药物治疗后，病变消失，仅留有瘢痕，1 年后无复发迹象。这是首例由苯基杆菌引起的皮肤感染性肉芽肿的病例报告。
