Marques A R, Kwon-Chung K J, Holland S M, Turner M L, Gallin J I
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886.
Clin Infect Dis. 1995 Jan;20(1):110-4. doi: 10.1093/clinids/20.1.110.
We describe a patient with chronic granulomatous disease who presented with erythematous papular skin lesions on the chest, back, and arm. Examination of biopsy specimens from the lesions on the arm and back showed suppurative granulomata in association with acute and chronic inflammation. Histopathologic examination of a specimen from the lesion on the arm revealed fungal elements, and cultures yielded Microascus cinereus. The patient was treated with 2.5 g of intravenous amphotericin B, and the lesions resolved. We report what is, to our knowledge, the first case of invasive disease due solely to M. cinereus.
我们描述了一名患有慢性肉芽肿病的患者，其胸部、背部和手臂出现红斑丘疹性皮肤病变。对手臂和背部病变的活检标本检查显示，有与急性和慢性炎症相关的化脓性肉芽肿。对手臂病变标本的组织病理学检查发现了真菌成分，培养结果为灰小孢霉。该患者接受了2.5克静脉注射两性霉素B治疗，病变得以消退。据我们所知，我们报告了首例仅由灰小孢霉引起的侵袭性疾病病例。
