Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Vaccine. 2010 May 21;28(23):3929-35. doi: 10.1016/j.vaccine.2010.03.067. Epub 2010 Apr 13.
The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults >or=65 years (P<0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.
老年人被认为是流感疫苗接种的优先群体，但他们的流感疫苗诱导抗体被认为下降得更快。与年轻人相比，评估了老年人流感疫苗的长期免疫原性。在接种前和接种后（接种后 1、6 和 12 个月）测定血清血凝素抑制（HI）滴度。在 1018 名受试者中，716 名（70.3%）在 12 个月的随访期内。根据年龄组和流感疫苗病毒株，接种后 1 个月的血清保护率范围为 70.1%至 90.3%。接种后 6 个月，所有三种菌株的血清保护率在≥65 岁的成年人中均显著下降（P<0.01），但仍符合 EMEA 标准。接种前 HI 滴度低（<1:40）和年龄较大与 HI 滴度的早期下降相关，在接种后大约 6 个月时下降到低于血清保护水平。
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