Department of Medicine (Cardiology) and Radiology, Stanford University School of Medicine, Stanford, California, USA.
J Nucl Med. 2010 May 1;51 Suppl 1(Suppl 1):128S-136S. doi: 10.2967/jnumed.109.068239. Epub 2010 Apr 15.
Molecular imaging is a new discipline that makes possible the noninvasive visualization of cellular and molecular processes in living subjects. In the field of cardiovascular regenerative therapy, imaging cell fate after transplantation is a high priority in both basic research and clinical translation. For cell-based therapy to truly succeed, we must be able to track the locations of delivered cells, the duration of cell survival, and any potential adverse effects. The insights gathered from basic research imaging studies will yield valuable insights into better designs for clinical trials. This review highlights the different types of stem cells used for cardiovascular repair, the development of various imaging modalities to track their fate in vivo, and the challenges of clinical translation of cardiac stem cell imaging in the future.
分子影像学是一门新兴学科，能够实现对活体中细胞和分子过程的非侵入性可视化。在心血管再生治疗领域，移植后细胞命运的成像在基础研究和临床转化中都是重中之重。为了使细胞治疗真正成功，我们必须能够追踪移植细胞的位置、细胞存活的时间以及任何潜在的不良反应。从基础研究成像研究中收集的见解将为临床试验的更好设计提供有价值的信息。这篇综述重点介绍了用于心血管修复的不同类型的干细胞，以及开发各种成像方式来跟踪它们在体内的命运，以及未来心脏干细胞成像的临床转化所面临的挑战。
