Suwalsky M, Neira F, Sánchez I
Department of Chemistry, University of Concepción, Chile.
Z Naturforsch C J Biosci. 1991 Jan-Feb;46(1-2):133-8. doi: 10.1515/znc-1991-1-221.
This study deals with the structural perturbations that the antibiotic chlortetracycline hydrochloride (CTC) can produce on phospholipid bilayers. Two multibilayer systems, one built-up of dimyristoylphosphatidylethanolamine (DMPE) and the other of dimyristoylphosphatidylcholine (DMPC) were allowed to interact with different concentrations of CTC in the absence and presence of water. The study was carried out by X-ray diffraction methods and all experiments were done below the phospholipid main transition temperatures. The results showed that CTC produced significant perturbations on DMPC even in the absence of water, whereas they were much milder in DMPE.
本研究探讨了抗生素盐酸金霉素（CTC）对磷脂双层结构的扰动作用。构建了两个多层体系，一个由二肉豆蔻酰磷脂酰乙醇胺（DMPE）组成，另一个由二肉豆蔻酰磷脂酰胆碱（DMPC）组成，并使其在有水和无水条件下与不同浓度的CTC相互作用。通过X射线衍射方法进行研究，所有实验均在磷脂主转变温度以下进行。结果表明，即使在无水条件下，CTC对DMPC也产生了显著的扰动，而对DMPE的扰动则要温和得多。
