神经疾病中的内源性锌。
Endogenous zinc in neurological diseases.
机构信息
Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea.
出版信息
J Clin Neurol. 2005 Oct;1(2):121-33. doi: 10.3988/jcn.2005.1.2.121. Epub 2005 Oct 20.
Abstract
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout Roman and modern times (for example, as the American lotion named for its zinc ore, 'Calamine'). It is, therefore, somewhat ironic that zinc is a relatively late addition to the pantheon of signal ions in biology and medicine. However, the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'. Here neurobiological roles of endogenous zinc is summarized.
摘要
古埃及纸莎草纸（例如，史密斯纸莎草纸）中就有提到将锌用于药用乳膏，显然，在罗马时期和现代，锌的使用一直相当稳定（例如，作为以其锌矿石命名的美国洗剂，“炉甘石”）。因此，锌是生物学和医学中信号离子的相对较晚的补充，这有点讽刺。但是，锌出现的生物功能，健康影响和药理靶标数量表明，它可能成为“二十一世纪的钙”。这里总结了内源性锌的神经生物学作用。
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