Department of Neurology, Konkuk University Hospital, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea.
J Clin Neurol. 2006 Sep;2(3):163-70. doi: 10.3988/jcn.2006.2.3.163. Epub 2006 Sep 20.
Matrix metalloproteinases (MMPs) are involved in the pathophysiology of several central nervous system diseases that share common pathogeneses, such as disruption of the blood-brain barrier (BBB), neuroinflammation, oxidative stress, and remodeling of the extracellular matrix (ECM). In early ischemic injury, MMPs participate in disruption of the BBB by digesting the basal lamina of capillaries and ECM, leading to vasogenic edema and hemorrhagic transformation. However, ECM degradation and remodeling are essential for tissue recovery, with MMPs having a key role as modulators of homeostasis between neuronal death and tissue regeneration. Thus, MMPs may be a double-edged sword that has a deleterious or beneficial role depending on the stage of brain injury.
基质金属蛋白酶（MMPs）参与了几种中枢神经系统疾病的病理生理学过程，这些疾病具有共同的发病机制，如血脑屏障（BBB）破坏、神经炎症、氧化应激和细胞外基质（ECM）重塑。在早期缺血性损伤中，MMPs 通过消化毛细血管基底膜和 ECM 参与 BBB 的破坏，导致血管源性水肿和出血性转化。然而，ECM 的降解和重塑对于组织恢复至关重要，MMPs 作为神经元死亡和组织再生之间平衡的调节剂起着关键作用。因此，MMPs 可能是一把双刃剑，其作用具有危害性或有益性，这取决于脑损伤的阶段。
