Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.
Mar Biotechnol (NY). 2011 Aug;13(4):622-8. doi: 10.1007/s10126-010-9292-0. Epub 2010 Apr 16.
Because of the importance of shrimp in world aquaculture, there is much interest in understanding their immune system in order to improve their resistance to pathogenic microorganisms. An effective tool in studying genes involved in the immune response in shrimp is RNA interference (RNAi). RNAi, first recognized as an antiviral response against RNA viruses, is a cellular mechanism that is triggered by double-stranded RNAs and results in the degradation of homologous genes. In this review, we describe the current studies of genes in shrimp that employed RNAi technology to elucidate or confirm their functions. We also review the potential of RNAi to elicit antiviral response in shrimp.
由于虾类在世界水产养殖中的重要性，人们非常关注了解它们的免疫系统，以提高它们对病原微生物的抵抗力。RNA 干扰（RNAi）是研究虾类免疫反应相关基因的有效工具。RNAi 最初被认为是一种针对 RNA 病毒的抗病毒反应，是一种由双链 RNA 触发的细胞机制，导致同源基因降解。在这篇综述中，我们描述了目前利用 RNAi 技术阐明或证实虾类基因功能的研究。我们还回顾了 RNAi 引发虾类抗病毒反应的潜力。
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