Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
Breast Cancer Res Treat. 2010 Dec;124(3):765-9. doi: 10.1007/s10549-010-0885-0. Epub 2010 Apr 16.
RAD51 plays a key role in homologous recombination repair of double-stranded DNA breaks which may cause chromosomal breaks and genomic instability. We performed a meta-analysis of 9 epidemiological studies involving 13,241 cases and 13,203 controls that examined the association between RAD51 135G>C polymorphism and breast cancer. No significant association of RAD51 135G>C polymorphism with breast cancer was found in overall and European populations. However, after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded, we observed an overall significant increased breast cancer risk (for the recessive model CC vs. GG/CG: OR = 1.35, 95% CI = 1.05-1.74, P (heterogeneity) = 0.06). In summary, our meta-analysis suggested the RAD51 135G > C polymorphism may contribute to breast cancer susceptibility.
RAD51 在双链 DNA 断裂的同源重组修复中发挥着关键作用,而双链 DNA 断裂可能导致染色体断裂和基因组不稳定。我们对 9 项涉及 13241 例病例和 13203 例对照的流行病学研究进行了荟萃分析,以检验 RAD51 135G>C 多态性与乳腺癌之间的关联。总体和欧洲人群中,RAD51 135G>C 多态性与乳腺癌均无显著相关性。然而,在排除不符合 Hardy-Weinberg 平衡的研究后,我们观察到总体上乳腺癌发病风险显著增加(对于隐性模型 CC 与 GG/CG:OR = 1.35,95%CI = 1.05-1.74,P(异质性)= 0.06)。综上所述,我们的荟萃分析表明 RAD51 135G>C 多态性可能与乳腺癌易感性相关。