Department of Epidemiology and Biostatistics, Nanjing Medical University, 210029, Nanjing, China.
Breast Cancer Res Treat. 2010 Sep;123(2):557-61. doi: 10.1007/s10549-010-0772-8. Epub 2010 Feb 9.
NBS1 gene plays an important role in DNA repair. Many epidemiological studies have investigated the association between NBS1 8360G > C polymorphism and breast cancer, however, the results are still controversial. Therefore, we performed a meta-analysis of 10 case-control studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. The results showed NBS1 8360G > C polymorphism contributed to breast risk in overall populations (for CC vs. GG: OR = 0.75, 95% CI = 0.74-0.98, P = 0.13 for heterogeneity; for the recessive model CC vs. GG/CG: OR = 0.88, 95% CI = 0.77-1.00, P = 0.44 for heterogeneity). In subgroup analysis by ethnicity, no significant association was found in all genetic models. In summary, our meta-analysis strongly suggests the NBS1 8360G > C polymorphism is associated with breast cancer.
NBS1 基因在 DNA 修复中发挥重要作用。许多流行病学研究已经调查了 NBS1 8360G>C 多态性与乳腺癌之间的关联，但结果仍存在争议。因此，我们对 10 项病例对照研究进行了荟萃分析。使用粗比值比（ORs）及其 95%置信区间（CIs）来评估关联的强度。结果表明，NBS1 8360G>C 多态性与总体人群的乳腺癌风险有关（对于 CC 与 GG：OR=0.75，95%CI=0.74-0.98，P=0.13 用于异质性；对于隐性模型 CC 与 GG/CG：OR=0.88，95%CI=0.77-1.00，P=0.44 用于异质性）。按种族亚组分析，所有遗传模型均未发现显著相关性。总之，我们的荟萃分析强烈表明 NBS1 8360G>C 多态性与乳腺癌相关。
