Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Mol Cells. 2010 May;29(5):435-42. doi: 10.1007/s10059-010-0067-2. Epub 2010 Apr 12.
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1 alpha, but also more cell-specific HIF-2 alpha, is an important regulator of the hypoxia response. Although both alpha subunits are highly conservative at protein level, share similar domain structure, heterodimerize with HIF-1 beta, and bind to the same DNA sequence called hypoxia responsive element (HRE), their effect on the expression of some genes may vary. In this review we stressed the differences between the isoforms, their structure and expression pattern. Moreover, we described diversity of coactivators and proteins which interact with HIFs, and which are responsible for the specificity of their action. Finally, recent data showing link between HIFs and specific microRNA have been presented.
缺氧诱导因子 (HIF)-1 和 HIF-2 是异二聚体转录因子，介导细胞对缺氧的反应。最近的数据表明，不仅普遍存在的 HIF-1α，而且更具细胞特异性的 HIF-2α，也是缺氧反应的重要调节剂。尽管两个α亚基在蛋白质水平上高度保守，具有相似的结构域结构，与 HIF-1β 异二聚化，并与相同的 DNA 序列（称为缺氧反应元件 (HRE)）结合，但它们对某些基因的表达的影响可能不同。在这篇综述中，我们强调了同工型之间的差异、它们的结构和表达模式。此外，我们还描述了与 HIF 相互作用的共激活因子和蛋白质的多样性，这些因子和蛋白质负责其作用的特异性。最后，还介绍了最近表明 HIFs 与特定 microRNA 之间存在联系的数据。
