School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Australia.
Res Sports Med. 2010 Apr;18(2):127-39. doi: 10.1080/15438621003627133.
It has been purported that inflammatory cytokines may be responsible for the aetiology of overtraining. The aim of the present study was to investigate the relationship between self-reported measures of overtraining and inflammatory cytokines. Eight elite male rowers were monitored in their natural training environment for 8 weeks prior to the 2007 Rowing World Championships. During this period of intense endurance training, self-report measures of overtraining and inflammatory cytokines (Interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12p70, and Tumor Necrosis Factor (TNF)-alpha) were assessed fortnightly. Consistent with previous findings, proinflammatory cytokines IL-1beta and TNF-alpha were significantly associated (p <or= 0.05) with measures of depressed mood, sleep disturbances, and stress. Similarly, IL-6 was significantly associated (p <or= 0.01) with measures of depressed mood, sleep disturbances, and fatigue. These results are consistent with previous hypotheses describing how overtraining may be caused by excessive cytokine release, and lend further support for a cytokine hypothesis of overtraining.
据称，炎症细胞因子可能是导致过度训练的病因。本研究的目的是探讨自报告的过度训练测量值与炎症细胞因子之间的关系。在 2007 年划船世界锦标赛之前，8 名男性精英划船运动员在自然训练环境中接受了 8 周的监测。在这个高强度耐力训练期间，每两周评估一次过度训练和炎症细胞因子（白细胞介素 (IL)-1beta、IL-6、IL-8、IL-10、IL-12p70 和肿瘤坏死因子 (TNF)-alpha）的自报告测量值。与先前的发现一致，促炎细胞因子 IL-1beta 和 TNF-alpha 与情绪低落、睡眠障碍和压力的测量值显著相关（p<0.05）。同样，IL-6 与情绪低落、睡眠障碍和疲劳的测量值显著相关（p<0.01）。这些结果与描述过度训练如何可能由过多细胞因子释放引起的先前假说一致，并进一步支持过度训练的细胞因子假说。
