Rutt Amy L, Hawkshaw Mary J, Sataloff Robert T
Department of Otolaryngology-Head and Neck Surgery, Huron Valley-Sinai Hospital, Detroit Medical Center/Wayne State University, Detroit, MI, USA.
Ear Nose Throat J. 2010 Apr;89(4):189-92.
Laryngeal cancer in patients younger than 30 years is uncommon. We present data on this population obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program. We identified 99 patients in this age group from the SEER 17 registry, which includes data submitted from 1973 through 2003. This population was made up of 52 females and 47 males; most were white, and most were aged 25 to 29 years. Malignancies of the glottis were the most common cancers, followed by supraglottic lesions. The 5-year relative survival rate was lowest among those aged 15 to 19 years-60.1%; 5-year relative survival among those aged 20 to 24 and 25 to 29 years was 87.7 and 87.4%, respectively. The etiology of squamous cell carcinoma (SCC) in children and adolescents remains uncertain, but in the adult population, a history of smoking, drinking, and poor oral hygiene cannot be ignored. Carcinoma of the larynx in young people has been related to malignant degeneration of papillomas and to complications of radiotherapy for papillomas. Infection with the human immunodeficiency virus possibly accelerates the development of SCC in patients with significant risk factors, presumably by impairing normal immune surveillance mechanisms.
30岁以下患者的喉癌并不常见。我们展示了从美国国立癌症研究所的监测、流行病学和最终结果（SEER）计划中获得的关于这一人群的数据。我们从SEER 17登记处确定了该年龄组的99名患者，该登记处包括1973年至2003年提交的数据。这一人群由52名女性和47名男性组成；大多数是白人，且大多数年龄在25至29岁之间。声门恶性肿瘤是最常见的癌症，其次是声门上病变。15至19岁人群的5年相对生存率最低，为60.1%；20至24岁和25至29岁人群的5年相对生存率分别为87.7%和87.4%。儿童和青少年鳞状细胞癌（SCC）的病因仍不确定，但在成年人群中，吸烟、饮酒和口腔卫生差的病史不容忽视。年轻人的喉癌与乳头状瘤的恶性变以及乳头状瘤放疗的并发症有关。感染人类免疫缺陷病毒可能会加速有重大危险因素患者的SCC发展，大概是通过损害正常的免疫监测机制。
