Dutta Rahul, Husain Qasim, Kam David, Dubal Pariket M, Baredes Soly, Eloy Jean Anderson
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Department of Otolaryngology-Head and Neck Surgery, Columbia University Medical Center, New York, New York, USA Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New York, USA.
Otolaryngol Head Neck Surg. 2015 Jul;153(1):54-9. doi: 10.1177/0194599815581613. Epub 2015 Apr 27.
Papillary squamous cell carcinoma has emerged as a distinct entity from the more common keratinizing squamous cell carcinoma. The basis behind this distinction relates not only to its histologic variation but also to its overall prognosis and survival. The objective of this study was to demonstrate the incidence, demographics, and long-term survival of laryngeal papillary squamous cell carcinoma (LPSCC) and how it relates to other laryngeal malignancies using a population-based database.
Analysis of a population-based tumor registry.
The United States National Cancer Institute's Surveillance, Epidemiology, and End Results registry was used to perform a retrospective analysis. Patients diagnosed with LPSCC from 1973 to 2011 were identified. Data endpoints extracted included patient demographics, incidence, and survival.
Three-hundred seventy cases of LPSCC were identified, corresponding to 0.5% of all laryngeal tumors. There was a 3:1 male predilection, without a significant racial preference. Most tumors identified were localized (T1) and at stage 1. The 1-year, 5-year, and 10-year disease-specific survival (DSS) for LPSCC was 97.1%, 83.1%, and 73.9%, respectively, compared with 87.9%, 64.5%, and 50.5% for other laryngeal malignancies (P values <.0001). Surgery was associated with a higher overall DSS in both LPSCC (87.4% vs 78.8%) and other laryngeal malignancies (70% vs 59.4%) when compared with other treatment modalities.
This analysis of the largest sample of LPSCC demonstrates a better prognosis for this pathology compared with other laryngeal malignancies.
乳头状鳞状细胞癌已成为一种与更常见的角化性鳞状细胞癌不同的独特实体。这种区别背后的依据不仅与其组织学差异有关，还与其总体预后和生存率有关。本研究的目的是利用基于人群的数据库，证明喉乳头状鳞状细胞癌（LPSCC）的发病率、人口统计学特征和长期生存率，以及它与其他喉恶性肿瘤的关系。
对基于人群的肿瘤登记处进行分析。
使用美国国立癌症研究所的监测、流行病学和最终结果登记处进行回顾性分析。确定1973年至2011年期间诊断为LPSCC的患者。提取的数据终点包括患者人口统计学特征、发病率和生存率。
共确定370例LPSCC病例，占所有喉肿瘤的0.5%。男性患病率为3:1，无明显种族倾向。大多数确诊肿瘤为局限性（T1）且处于1期。LPSCC的1年、5年和10年疾病特异性生存率（DSS）分别为97.1%、83.1%和73.9%，而其他喉恶性肿瘤分别为87.9%、64.5%和50.5%（P值<0.0001）。与其他治疗方式相比，手术在LPSCC（87.4%对78.8%）和其他喉恶性肿瘤（70%对59.4%）中均与更高的总体DSS相关。
对最大样本的LPSCC进行的这项分析表明，与其他喉恶性肿瘤相比，这种病理类型的预后更好。
