趋化因子与肝细胞癌。
Chemokines and hepatocellular carcinoma.
机构信息
Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
出版信息
World J Gastroenterol. 2010 Apr 21;16(15):1832-6. doi: 10.3748/wjg.v16.i15.1832.
Abstract
Chemokines play a paramount role in tumor progression. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this paper, several chemokines and their receptor interactions in HCC progression, growth and metastasis and immune response to HCC are reviewed.
摘要
趋化因子在肿瘤进展中起着至关重要的作用。在肝细胞癌 (HCC) 进展中，趋化因子及其受体起着复杂的作用。目前，趋化因子及其受体（如 CXCL12-CXCR4 轴、CX3CL1-CX3CR1 轴和 CCL20-CCR6 轴）受到了广泛的关注。尽管大量研究表明这些轴与 HCC 密切相关，但这些轴促进 HCC 生长和进展的确切机制尚不清楚。本文综述了 HCC 进展、生长和转移以及 HCC 免疫反应中几种趋化因子及其受体的相互作用。
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